Anti-NOP2 Antibody Picoband®

Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus.

NACHT, LRR and PYD domains-containing protein 2; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; NLRP2; NALP2; NBS1; PAN1; PYPAF2

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

1. Baens, M., Chaffanet, M., Aerssens, J., Cassiman, J.-J., Marynen, P. Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids. Genomics 21: 296-297, 1994. 2. Fonagy, A., Swiderski, C., Wilson, A., Bolton, W., Kenyon, N., Freeman, J. W. Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts. J. Cell. Physiol. 154: 16-27, 1993. 3. Freeman, J. W., Busch, R. K., Gyorkey, F., Gyorkey, P., Ross, B. E., Busch, H. Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase. Cancer Res. 48: 1244-1251, 1988.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.