Anti-DAX-1/NR0B1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is a nuclear receptor protein that in humans is encoded by the NR0B1 gene (nuclear receptor subfamily 0, group B, member 1) . This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.

Synonyms

Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94

Gene Name

NR0B1

Gene ID

190

UniProt

P51843

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human DAX-1/NR0B1 recombinant protein (Position: V126-Q404) .

Clonality

Polyclonal

Tissue Specificity

Selectively expressed by both resting and activated NK cells.

Applications

Flow Cytometry

Field of Research

Adapters, Adaptive Immunity, Immunology, Signal Transduction, T Cells, Transmembrane

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

References & Citations

1. Achermann, J. C., Gu, W.-X., Kotlar, T. J., Meeks, J. J., Sabacan, L. P., Seminara, S. B., Habiby, R. L., Hindmarsh, P. C., Bick, D. P., Sherins, R. J., Crowley, W. F., Jr., Layman, L. C., Jameson, J. L. Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. J. Clin. Endocr. Metab. 84: 4497-4500, 1999. 2. Achermann, J. C., Ito, M., Ito, M., Hindmarsh, P. C., Jameson, J. L. A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. (Letter) Nature Genet. 22: 125-126, 1999. 3. Achermann, J. C., Silverman, B. L., Habiby, R. L., Jameson, J. L. Presymptomatic diagnosis of X-linked adrenal hypoplasia congenita by analysis of DAX1. J. Pediat. 137: 878-881, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

Gene Name Synonym

Natural cytotoxicity triggering receptor 1

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Name

Platelet endothelial cell adhesion molecule

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-DAX-1/NR0B1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

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