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Anti-PTGR2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants.

Synonyms

Protein NDRG3; N-myc downstream-regulated gene 3 protein; NDRG3

Gene Name

PTGR2

Gene ID

145482

UniProt

Q8N8N7

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human PTGR2 recombinant protein (Position: E26-Q305) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highly expressed in brain. .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Differentiation, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

References & Citations

1. Yun-Chia, C. E. , Yi-Cheng, C. , Chia-Tung, S. , Yu-Wen, T. , Shu-Huei, T. , & Siow-Wey, H. , et al. (2016) . Inhibition of prostaglandin reductase 2, a putative oncogene overexpressed in human pancreatic adenocarcinoma, induces oxidative stress-mediated cell death involving xct and cth gene expressions through 15-keto-pge2. Plos One, 11 (1), e0147390. 2. Yun-Chia Chang, E. , Tsai, S. H. , Shun, C. T. , Hee, S. W. , Chang, Y. C. , & Tsai, Y. C. , et al. (2012) . Prostaglandin reductase 2 modulates ros-mediated cell death and tumor transformation of gastric cancer cells and is associated with higher mortality in gastric cancer patients. American Journal of Pathology, 181 (4), 1316-1326. 3. Gao, K. , Lockwood, W. , Li, J. , Lam, W. , & Li, G. . (2008) . Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells. International Journal of Oncology, 32 (6), 1343-1349.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41409 MW

Applications Notes

6

Gene Name Synonym

Protein NDRG3

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

Protein NDRG3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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