Anti-NPFFR2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene. This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants.
Synonyms
Disintegrin and metalloproteinase domain-containing protein 2; ADAM 2; Cancer/testis antigen 15; CT15; Fertilin subunit beta; PH-30; PH30; PH30-beta; ADAM2; FTNB
Gene Name
NPFFR2
Gene ID
10886
UniProt
Q9Y5X5
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NPFFR2 recombinant protein (Position: L14-E521) .
Clonality
Polyclonal
Tissue Specificity
Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
References & Citations
1. Bonini, J. A., Jones, K. A., Adham, N., Forray, C., Artymyshyn, R., Durkin, M. M., Smith, K. E., Tamm, J. A., Boteju, L. W., Lakhlani, P. P., Raddatz, R., Yao, W.-J., Ogozalek, K. L., Boyle, N., Kouranova, E. V., Quan, Y., Vaysse, P. J, Wetzel, J. M., Branchek, T. A., Gerald, C., Borowsky, B. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. J. Biol. Chem. 275: 39324-39331, 2000. 2. Cikos, S., Gregor, P., Koppel, J. Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta. Biochem. Biophys. Res. Commun. 256: 352-356, 1999. 3. Dahlman, I., Dicker, A., Jiao, H., Kere, J., Blomqvist, L., van Harmelen, V., Hoffstedt, J., Borch-Johnsen, K., Jorgensen, T., Hansen, T., Pedersen, O., Laakso, M., Arner, P. A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. Am. J. Hum. Genet. 80: 1115-1124, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
82457 MW
Applications Notes
6
Gene Name Synonym
Disintegrin and metalloproteinase domain-containing protein 2
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Disintegrin and metalloproteinase domain-containing protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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