Chlorquinaldol

Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells[1][2].

Product Specifications

CAS Number

[72-80-0]

Product Name Alternative

Chloquinan

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Apoptosis; Bacterial; Fungal; β-catenin

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Chlorquinaldol.html

Purity

98.69

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C2N=C(C)C=CC2=C(Cl)C=C1Cl

Molecular Formula

C10H7Cl2NO

Molecular Weight

228.08

Precautions

H302

References & Citations

[1]Bortolin M, et al. In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid. Front Microbiol. 2017 Jun 8;8:1039.|[2]Wang L, et al. Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity. Pharmacol Res. 2020 Sep;159:104955.