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Anti-PUS7 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Enables enzyme binding activity and pseudouridine synthase activity. Involved in several processes, including pseudouridine synthesis; regulation of hematopoietic stem cell differentiation; and regulation of mesoderm development. Located in nucleus.

Synonyms

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

Gene Name

PUS7

Gene ID

54517

UniProt

Q96PZ0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human PUS7 recombinant protein (Position: D294-H541) .

Clonality

Polyclonal

Tissue Specificity

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Applications

Flow Cytometry

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

References & Citations

1. de Brouwer, A. P. M., Abou Jamra, R., Kortel, N., Soyris, C., Polla D. L., Safra, M., Zisso, A., Powell, C. A., Rebelo-Guiomar, P., Dinges, N., Morin, V., Stock, M., and 16 others. Variants in PUS7 cause intellectual disability with speech delay, microcephaly, short stature, and aggressive behavior. Am. J. Hum. Genet. 103: 1045-1052, 2018. 2. Han, S. T., Kim, A. C., Garcia, K., Schimmenti, L. A., Macnamara, E., Undiagnosed Diseases Network, Gahl, W. A., Malicdan, M. C., Tifft, C. J. PUS7 deficiency in human patients causes profound neurodevelopmental phenotype by dysregulating protein translation. Molec. Genet. Metab. 135: 221-229, 2022. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 3/10/2015.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

75 kDa

Applications Notes

6

Gene Name Synonym

RNA-binding protein 47

Subcellular Location

Nucleus .

Protein Name

Follicular dendritic cell secreted peptide

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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