Anti-NFKBIZ Antibody Picoband® Fluoro647 Conjugated

NF-kappa-B inhibitor zeta (IκBζ) is a protein that in humans is encoded by the NFKBIZ gene.This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS) . The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

Cell Biology, Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Interferons, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin & Ubiquitin Like Modifiers, Ubiquitin E3 Enzymes

1. Bambouskova, M., Gorvel, L., Lampropoulou, V., Sergushichev, A., Loginicheva, E., Johnson, K., Korenfeld, D., Mathyer, M. E., Kim, H., Huang, L.-H., Duncan, D., Bregman, H., and 19 others. Electrophilic properties of itaconate and derivatives regulate the I-kappa-B-zeta-ATF3 inflammatory axis. Nature 556: 501-504, 2018. 2. Eto, A., Muta, T., Yamazaki, S., Takeshige, K. Essential roles for NF-kappa-B and a Toll/IL-1 receptor domain-specific signal (s) in the induction of I-kappa-B-zeta. Biochem. Biophys. Res. Commun. 301: 495-501, 2003. 3. Gross, M. B. Personal Communication. Baltimore, Md. 5/19/2020.