Anti-NR1/NDOR1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
NADPH-dependent diflavin oxidoreductase 1 is an enzyme that in humans is encoded by the NDOR1 gene. This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants.
Synonyms
B-cell differentiation antigen CD72; Lyb-2; CD72; CD72
Gene Name
NDOR1
Gene ID
27158
UniProt
Q9UHB4
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NR1/NDOR1 recombinant protein (Position: R31-Q407) .
Clonality
Polyclonal
Tissue Specificity
Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in B-cell proliferation and differentiation.
References & Citations
1. Kwasnicka, D. A., Krakowiak, A., Thacker, C., Brenner, C., Vincent, S. R. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-ed hydrolase, DCS-1. J. Biol. Chem. 278: 39051-39058, 2003. 2. Kwasnicka-Crawford, D. A., Vincent, S. R. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. Biochem. Biophys. Res. Commun. 336: 565-571, 2005. 3. Paine, M. J. I., Garner, A. P., Powell, D., Sibbald, J., Sales, M., Pratt, N., Smith, T., Tew, D. G., Wolf, C. R. Cloning and characterization of a novel human dual flavin reductase. J. Biol. Chem. 275: 1471-1478, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
CD72 molecule
Subcellular Location
Membrane; Single-pass type II membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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