Anti-NCBP1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay.
Synonyms
BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5; BAG5; KIAA0873
Gene Name
NCBP1
Gene ID
4686
UniProt
Q09161
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NCBP1 recombinant protein (Position: Y121-A790) .
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues examined with lower levels in brain and testis.
Applications
Flow Cytometry
Field of Research
Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .
References & Citations
1. Chadwick, B. P., Obermayr, F., Frischauf, A.-M. Nuclear cap binding protein maps close to the xeroderma pigmentosum complementation group A (XPA) locus in human and mouse. Genomics 35: 632-633, 1996. 2. Ishigaki, Y., Li, X., Serin, G., Maquat, L. E. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell 106: 607-617, 2001. 3. Izaurralde, E., Lewis, J., McGulian, M., Jankowska, E., Darzynkewicz, E., Mattaj, I. W. A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell 78: 657-668, 1994.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
51200 MW
Applications Notes
6
Gene Name Synonym
BAG family molecular chaperone regulator 5
Subcellular Location
Perinuclear region.
Protein Name
BAG family molecular chaperone regulator 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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