Anti-NCAPH Antibody Picoband® Fluoro488 Conjugated

Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a protein that in humans is encoded by the NCAPH gene. This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Aono, N., Sutani, T., Tomonaga, T., Mochida, S., Yanagida, M. Cnd2 has dual roles in mitotic condensation and interphase. Nature 417: 197-202, 2002. 2. Bhat, M. A., Philp, A. V., Glover, D. M., Bellen, H. J. Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with topoisomerase II. Cell 87: 1103-1114, 1996. 3. Cabello, O. A., Baldini, A., Bhat, M., Bellen, H., Belmont, J. W. Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2. Genomics 46: 311-313, 1997.