Anti-PPP3R1 Antibody Picoband® Fluoro647 Conjugated

Calcineurin, the Ca (2+) /calmodulin-regulated protein phosphatase, first detected in skeletal muscle and brain, has been found in all cells from yeast to mammals. Calcineurin A alpha (PPP3CA), is located on human chromosomes 4, Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. Calcineurin regulates bone formation by the osteoblast.

Mediator of RNA polymerase II transcription subunit 4; Activator-recruited cofactor 36 kDa component; ARC36; Mediator complex subunit 4; TRAP/SMCC/PC2 subunit p36 subunit; Vitamin D3 receptor-interacting protein complex 36 kDa component; DRIP36; MED4; ARC36; DRIP36; VDRIP; HSPC126

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Giri, P.; Higuchi, S.; Kincaid, R. L. : Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. Biochem. Biophys. Res. Commun. 181: 252-258, 1991. 2. Sun, L.; Blair, H. C.; Peng, Y.; Zaidi, N.; Adebanjo, O. A.; Wu, X. B.; Wu, X. Y.; Iqbal, J.; Epstein, S.; Abe, E.; Moonga, B. S.; Zaidi, M. : Calcineurin regulates bone formation by the osteoblast. Proc. Nat. Acad. Sci. 102: 17130-17135, 2005. 3. Wang, M. G.; Yi, H.; Guerini, D.; Klee, C. B.; McBride, O. W. : Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-q22 and 2p16-p15 respectively. Cytogenet. Cell Genet. 72: 236-241, 1996.