Anti-PFKFB1 Antibody Picoband® Fluoro488 Conjugated

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Disintegrin and metalloproteinase domain-containing protein 2; ADAM 2; Cancer/testis antigen 15; CT15; Fertilin subunit beta; PH-30; PH30; PH30-beta; ADAM2; FTNB

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

1. Algaier, J., Uyeda, K. Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6,2-kinase:fructose-2,6-bisphosphatase. Biochem. Biophys. Res. Commun. 153: 328-333, 1988. 2. Batra, R. S., Hatchwell, E., Rider, S., Brown, R., Brown, G. K., Craig, I. W. Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21. Genomics 40: 358-361, 1997. 3. Darville, M. I., Crepin, K. M., Vanderkerckhove, J., Van Damme, J., Octave, J. N., Rider, M. H., Marchand, M. J., Hue, L., Rousseau, G. G. Complete nucleotide sequence coding for rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase derived from a cDNA clone. FEBS Lett. 224: 317-321, 1987.