Anti-SERPINB9 Antibody Picoband® Fluoro488 Conjugated

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene. This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6.

Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

1. Barrie, M. B., Stout, H. W., Abougergi, M. S., Miller, B. C., Thiele, D. L. Antiviral cytokines induce hepatic expression of the granzyme B inhibitors, proteinase inhibitor 9 and serine proteinase inhibitor 6. J. Immun. 172: 6453-6459, 2004. 2. Bladergroen, B. A., Strik, M. C. M., Bovenschen, N., van Berkum, O., Scheffer, G. L., Meijer, C. J. L. M., Hack, C. E., Kummer, J. A. The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. J. Immun. 166: 3218-3225, 2001. 3. Eyre, H. J., Sun, J., Sutherland, G. R., Bird, P. Chromosomal mapping of the gene (PI9) encoding the Fixed serpin proteinase inhibitor 9 to 6p25 by fluorescence in situ hybridization. Genomics 37: 406-408, 1996.