Anti-SCFD2 Antibody Picoband® Fluoro488 Conjugated

SCFD2 (sec1 family domain containing 2), also known as STXBP1L1 (syntaxinbinding protein 1-like 1), is a 684 amino acid protein suggested to play a role in protein transport. Existing as two alternatively spliced isoforms, SCFD2 is a member of the STXBP/unc-18/SEC1 family and is encoded by a gene that maps to human chromosome 4q12. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington’s disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Mitobe, Y. , Iino, K. , Takayama, K. , Ikeda, K. , Suzuki, T. , & Aogi, K. , et al. (2020) . Psf promotes er-positive breast cancer progression via posttranscriptional regulation of esr1 and scfd2. Cancer research, 80 (11), 2230-2242. 2. Takeiwa, T. , Ikeda, K. , Suzuki, T. , Sato, W. , Iino, K. , & Mitobe, Y. , et al. (2022) . Pspc1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates rna processing of esr1 and scfd2. Scientific reports, 12 (1), 9495. 3. (2010) . Genome-wide association identifies atoh7 as a major gene determining human optic disc size. Human Molecular Genetics, 19 (13), 2716.