Anti-PRRC1 Antibody Picoband®

PRRC1 (Proline-Rich Coiled-Coil 1) is a Protein Coding gene. The PRRC1 gene, located on 5q23.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The PRCC1 gene has two distinct regions: a proline-rich region on the N-terminus, and the DUF84 region on the C-terminus. PRCC1 is the commonly identified protein name of CAD38605. It encodes for 445 amino acids for a predicted total of 6 exons. The predicted molecular weight is 46.7 kDa, and the isoelectric point is 5.46. Orthologs have been determined in most eukaryotes, the most highly conserved being found in most mammalian species. PRRC1 is widely expressed in the thyroid, endometrium, and other tissues. Diseases associated with PRRC1 include Dystonia 23.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Kamakari, S. , Roussou, A. , Jefferson, A. , Ragoussis, I. , & Anagnou, N. P. . (2005) . Structural analysis and expression profile of a novel gene on chromosome 5q23 encoding a golgi-associated protein with six splice variants, and involved within the 5q deletion of a ph (-) cml patient. Leukemia Research, 29 (1), 17-31. 2. WW Domains Provide a Platform for the Assembly of Multiprotein Networks.[J]. Molecular & Cellular Biology, 2005. 3. St-Denis, N. , Gupta, G. D. , Lin, Z. Y. , Gonzalez-Badillo, B. , Pelletier, L. , & Gingras, A. C. . (2015) . Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kda to ensure proper abscission. Molecular & Cellular Proteomics.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.