Anti-NDRG4 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.
Synonyms
Transmembrane protein 107; TMEM107; DC20, UNQ638/PRO1268
Gene Name
NDRG4
Gene ID
65009
UniProt
Q9ULP0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human NDRG4 recombinant protein (Position: M1-R226) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitous. .
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity) . .
References & Citations
1. Hirosawa, M., Nagase, T., Ishikawa, K., Kikuno, R., Nomura, N., Ohara, O. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. DNA Res. 6: 329-336, 1999. 2. Hongo, S., Watanabe, T., Takahashi, K., Miyazaki, A. Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. J. Cell. Biochem. 98: 185-193, 2006. 3. Linhares, N. D., Freire, M. C. M., Cardenas, R. G. C. C. L., Pena, H. B., Bahia, M., Pena, S. D. J. Exome sequencing identifies a novel homozygous variant in NDRG4 in a family with infantile myofibromatosis. Europ. J. Med. Genet. 57: 643-648, 2014.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
15503 MW
Applications Notes
6
Gene Name Synonym
Transmembrane protein 107
Subcellular Location
Membrane ; Multi-pass membrane protein .
Protein Name
Transmembrane protein 107
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items