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Anti-NDRG4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.

Synonyms

Transmembrane protein 107; TMEM107; DC20, UNQ638/PRO1268

Gene Name

NDRG4

Gene ID

65009

UniProt

Q9ULP0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human NDRG4 recombinant protein (Position: M1-R226) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. .

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity) . .

References & Citations

1. Hirosawa, M., Nagase, T., Ishikawa, K., Kikuno, R., Nomura, N., Ohara, O. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. DNA Res. 6: 329-336, 1999. 2. Hongo, S., Watanabe, T., Takahashi, K., Miyazaki, A. Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. J. Cell. Biochem. 98: 185-193, 2006. 3. Linhares, N. D., Freire, M. C. M., Cardenas, R. G. C. C. L., Pena, H. B., Bahia, M., Pena, S. D. J. Exome sequencing identifies a novel homozygous variant in NDRG4 in a family with infantile myofibromatosis. Europ. J. Med. Genet. 57: 643-648, 2014.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

15503 MW

Applications Notes

6

Gene Name Synonym

Transmembrane protein 107

Subcellular Location

Membrane ; Multi-pass membrane protein .

Protein Name

Transmembrane protein 107

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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