Anti-C7orf47/PPP1R35 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
PPP1R35 is a putative regulator of protein phosphatase-1. PPP1R35 is a centrosomal protein that regulates centriole elongation and centriole-to-centrosome conversion. Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity.
Synonyms
Transmembrane protein 240; TMEM240; C1orf70
Gene Name
PPP1R35
Gene ID
221908
UniProt
Q8TAP8
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human C7orf47/PPP1R35 recombinant protein (Position: E27-A253) .
Clonality
Polyclonal
Tissue Specificity
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
References & Citations
1. Fong, C. S., Ozaki, K., Tsou, M.-F. B. PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion. Molec. Biol. Cell 29: 2801-2808, 2018. 2. Gross, M. B. Personal Communication. Baltimore, Md. 7/1/2020. 3. Hendrickx, A., Beullens, M., Ceulemans, H., Abt, T. D., Van Eynde, A., Nicolaescu, E., Lesage, B., Bollen, M. Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem. Biol. 16: 365-371, 2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
19908 MW
Applications Notes
6
Gene Name Synonym
Transmembrane protein 240
Subcellular Location
Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .
Protein Name
Transmembrane protein 240
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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