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Anti-PSAT1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Phosphoserine aminotransferase (PSA), also known as phosphohydroxythreonine aminotransferase (PSAT), is an enzyme that in humans is encoded by the PSAT1 gene. This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants.

Synonyms

ELAV-like protein 2; ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1; ELAVL2; HUB

Gene Name

PSAT1

Gene ID

29968

UniProt

Q9Y617

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PSAT1 recombinant protein (Position: M1-K363) .

Clonality

Polyclonal

Tissue Specificity

Brain; neural-specific.

Applications

Flow Cytometry

Field of Research

DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.

References & Citations

1. Hart CE, Race V, Achouri Y, Wiame E, Sharrard M, Olpin SE, Watkinson J, Bonham JR, Jaeken J, Matthijs G, Van Schaftingen E (2007) . Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway. Am. J. Hum. Genet. 80 (5) : 931–7. 2. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (2011) . A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474 (7351) : 337–342.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

49655 MW

Applications Notes

6

Gene Name Synonym

ELAV like RNA binding protein 2

Subcellular Location

Cytoplasm. Nucleus. Cytoplasm.

Protein Name

AP-2 complex subunit mu

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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