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Anti-PRTFDC1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation.

Synonyms

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

Gene Name

PRTFDC1

Gene ID

5652

UniProt

Q9NRG1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PRTFDC1 recombinant protein (Position: E6-V225) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Applications

Flow Cytometry

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

References & Citations

1. Keebaugh, A. C., Sullivan, R. T., NISC Comparative Sequencing Program, Thomas, J. W. Gene duplication and inactivation in the HPRT gene family. Genomics 89: 134-142, 2007. 2. Suzuki, E., Imoto, I., Pimkhaokham, A., Nakagawa, T., Kamata, N., Kozaki, K., Amagasa, T., Inazawa, J. PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Oncogene 26: 7921-7932, 2007.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

26 kDa

Applications Notes

6

Gene Name Synonym

Eva-1 homolog A, regulator of programmed cell death

Subcellular Location

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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