What sizes are available for Anti-PDCD4 Antibody Picoband® Fluoro550 Conjugated?

Anti-PDCD4 Antibody Picoband® Fluoro550 Conjugated is available in the following size(s): 100 µg/Vial.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

Anti-PDCD4 Antibody Picoband® Fluoro550 Conjugated

Q: What is the catalog number for Anti-PDCD4 Antibody Picoband® Fluoro550 Conjugated?

The catalog number for Anti-PDCD4 Antibody Picoband® Fluoro550 Conjugated is A01105-4-Fluoro550.

Q: Is Anti-PDCD4 Antibody Picoband® Fluoro550 Conjugated in stock?

Anti-PDCD4 Antibody Picoband® Fluoro550 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Selected Variant

A01105-4-Fluoro550

Size: 100 µg/Vial

Product Specifications

Background

Programmed cell death protein 4 (PDCD4) is a protein that in humans is encoded by the PDCD4 gene. It is mapped to 10q25.2. This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. It also encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined.

Synonyms

Programmed cell death protein 4; Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a; PDCD4; H731

Gene Name

PDCD4

Gene ID

27250

UniProt

Q53EL6

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PDCD4 recombinant protein (Position: D160-L363) .

Clonality

Polyclonal

Tissue Specificity

Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. .

Applications

Flow Cytometry

Field of Research

Apoptosis, Cancer, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Cell Death, Epigenetics and Nuclear Signaling, Invasion/Microenvironment, Nucleus, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity) . .

References & Citations

1. Azzoni, L; Zatsepina, O; Abebe, B; Bennett, IM; Kanakaraj, P; Perussia, B (1998) . Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. Journal of immunology 161 (7) : 3493–500. 2. Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002) . Up-regulation of PDCD4 in senescent human diploid fibroblasts. Biochemical and Biophysical Research Communications. 293 (1) : 617–21.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

51735 MW

Applications Notes

Gene Name Synonym

Programmed cell death protein 4

Subcellular Location

Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.

Protein Name

Putative Polycomb group protein ASXL1

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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