Anti-PLET1 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
PLET-1 (placenta -expressed transcript 1), also known as antigen mAgK114, is a 23 kDa membrane protein that is probably GPI-anchored. It is recognized by the antibodies MTS20 and MTS24. Mature mouse PLET-1, which most likely includes amino acids (aa) 28-216 of 237 aa, shares less than 60% aa sequence identity with the most closely related rat or human protein. A potential 194 aa mouse splice variant diverges after aa 149 but still contains a hydrophobic sequence at the Cterminus. PLET-1 is a marker of early thymic progenitor cells and pancreatic duct epithelium.
Synonyms
Transmembrane protein 240; TMEM240; C1orf70
Gene Name
PLET1
Gene ID
349633
UniProt
Q6UQ28
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PLET1 recombinant protein (Position: D46-K166) .
Clonality
Polyclonal
Tissue Specificity
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Applications
Flow Cytometry
Field of Research
Cell Biology
Purification
Immunogen affinity purified.
Form
Liquid
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
References & Citations
1. Depreter, M. G. L., Blair, N. F., Gaskell, T. L., Nowell, C. S., Davern, K., Pagliocca, A., Stenhouse, F. H., Farley, A. M., Fraser, A., Vrana, J., Robertson, K., Morahan, G., Tomlinson, S. R., Blackburn, C. C. Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. Proc. Nat. Acad. Sci. 105: 961-966, 2008. 2. Zhao, S.-H., Simmons, D. G., Cross, J. C., Scheetz, T. E., Casavant, T. L., Soares, M. B., Tuggle, C. K. PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human. Genomics 84: 114-125, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
19908 MW
Applications Notes
6
Gene Name Synonym
Transmembrane protein 240
Subcellular Location
Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .
Protein Name
Transmembrane protein 240
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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