Anti-PILRA Antibody Picoband® Fluoro488 Conjugated

Paired immunoglobin like type 2 receptor alpha is a protein that in humans is encoded by the PILRA gene. Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM) -bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .

1. Fournier, N., Chalus, L., Durand, I., Garcia, E., Pin, J.-J., Churakova, T., Patel, S., Zlot, C., Gorman, D., Zurawski, S., Abrams, J., Bates, E. E. M., Garrone, P. FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J. Immun. 165: 1197-1209, 2000. 2. Kogure, A., Shiratori, I., Wang, J., Lanier, L. L., Arase, H. PANP is a novel O-glycosylated PILR-alpha ligand expressed in neural tissues. Biochem. Biophys. Res. Commun. 405: 428-433, 2011. 3. Mousseau, D. D., Banville, D., L'Abbe, D., Bouchard, P., Shen, S.-H. PILR-alpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILR-beta. J. Biol. Chem. 275: 4467-4474, 2000.