Anti-PPP4C Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene. Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane.
Synonyms
Rho-related GTP-binding protein Rho6; Rho family GTPase 1; Rnd1; RND1; RHO6
Gene Name
PPP4C
Gene ID
5531
UniProt
P60510
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PPP4C recombinant protein (Position: Q13-L307) .
Clonality
Polyclonal
Tissue Specificity
Mostly expressed in brain and liver.
Applications
Flow Cytometry
Field of Research
Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, G Protein Signaling, Microfilaments, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. .
References & Citations
1. Bastians, H., Krebber, H., Hoheisel, J., Ohl, S., Lichter, P., Ponstingl, H., Joos, S. Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization. Genomics 42: 181-182, 1997. 2. Brewis, N. D., Cohen, P. T. W. Protein phosphatase X has been highly conserved during mammalian evolution. Biochim. Biophys. Acta 1171: 231-233, 1992. 3. Chen, G. I., Tisayakorn, S., Jorgensen, C., D'Ambrosio, L. M., Goudreault, M., Gingras, A.-C. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. J. Biol. Chem. 283: 29273-29284, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
26056 MW
Applications Notes
6
Gene Name Synonym
Rho-related GTP-binding protein Rho6
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton .
Protein Name
AP-2 complex subunit mu
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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