Anti-Angiogenin/Ang Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Angiogenin (ANG) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene. Predicted to enable several functions, including actin binding activity; heparin binding activity; and protein homodimerization activity. Involved in liver development. Predicted to be located in several cellular components, including growth cone; neuronal cell body; and nucleolus. Predicted to be part of angiogenin-PRI complex. Human ortholog (s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple) ; and prostate cancer. Orthologous to human ANG (angiogenin) .
Synonyms
Angiogenin;3.1.27.-; Ribonuclease 5; RNase 5; ANG; RNASE5
Gene Name
Ang
Gene ID
305843
UniProt
Q5WRG2
Host
Rabbit
Reactivity
Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived rat Angiogenin/Ang recombinant protein (Position: Q25-L145) .
Clonality
Polyclonal
Tissue Specificity
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. .
Applications
Flow Cytometry
Field of Research
Actin Binding Proteins, Actin, etc., Angiogenesis, Cancer, Cancer Metabolism, Cardiovascular, Cytoskeleton, Cytoskeleton/ECM, DNA/RNA, Epigenetics and Nuclear Signaling, Hypoxia, Invasion/Microenvironment, Metabolism, Metabolism Processes, Microfilaments, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes, Response To Hypoxia, RNA Processing, Signal Transduction, Translation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) . Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. .
References & Citations
1. Brown, W. E., Nobile, V., Subramanian, V., Shapiro, R. The mouse angiogenin gene family: structures of an angiogenin-related protein gene and two pseudogenes. Genomics 29: 200-206, 1995. 2. Crabtree, B., Thiyagarajan, N., Prior, S. H., Wilson, P., Iyer, S., Ferns, T., Shapiro, R., Brew, K., Subramanian, V., Acharya, K. R. Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis. Biochemistry 46: 11810-11818, 2007. 3. Gao, X., Hu, H., Zhu, J., Xu, Z. Identification and characterization of follistatin as a novel angiogenin-binding protein. FEBS Lett. 581: 5505-5510, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
16550 MW
Applications Notes
6
Gene Name Synonym
Angiogenin
Subcellular Location
Nucleus . Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
Protein Name
Angiogenin
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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