Anti-PDS5B Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Sister chromatid cohesion protein PDS5 homolog B (PDS5B) is a protein that in humans is encoded by the PDS5B gene. This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene.
Synonyms
NACHT, LRR and PYD domains-containing protein 2; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; NLRP2; NALP2; NBS1; PAN1; PYPAF2
Gene Name
PDS5B
Gene ID
23047
UniProt
Q9NTI5
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PDS5B recombinant protein (Position: Q499-Q1424) .
Clonality
Polyclonal
Tissue Specificity
Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
Applications
Flow Cytometry
Field of Research
Apoptosis, Caspases, Cell Biology, Intracellular
Purification
Immunogen affinity purified.
Form
Liquid
Function
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
References & Citations
1. Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S., Hay, R. T. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Biochem. J. 451: 185-194, 2013. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 04/21/2017. 3. Ishikawa, K., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
NLR family pyrin domain containing 2
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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