Anti-RBM15 Antibody Picoband®

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene. Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590) . Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590) . Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity) . Modulates prostaglandin E2 secretion (PubMed:21242590) .

1. Hiriart, E., Gruffat, H., Buisson, M., Mikaelian, I., Keppler, S., Meresse, P., Mercher, T., Bernard, O. A., Sergeant, A., Manet, E. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. J. Biol. Chem. 280: 36935-36945, 2005. 2. Horiuchi, K., Kawamura, T., Iwanari, H., Ohashi, R., Naito, M., Kodama, T., Hamakubo, T. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. J. Biol. Chem. 288: 33292-33302, 2013. 3. Ma, Z., Morris, S. W., Valentine, V., Li, M., Herbrick, J.-A., Cui, X., Bouman, D., Li, Y., Mehta, P. K., Nizetic, D., Kaneko, Y., Chan, G. C. F., Chan, L. C., Squire, J., Scherer, S. W., Hitzler, J. K. Fusion of two novel genes, RBM15 and MKL1, in the t (1;22) (p13; q13) of acute megakaryoblastic leukemia. Nature Genet. 28: 220-221, 2001.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.