Anti-Recoverin/RCVRN Antibody Picoband® Fluoro647 Conjugated

This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy.

Disintegrin and metalloproteinase domain-containing protein 28; ADAM 28;3.4.24.-; Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; eMDC II; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; MDC-L; ADAM28; ADAM23, MDCL

Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.

May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

1. Bayes, M., Valverde, D., Balcells, S., Grinberg, D., Vilageliu, L., Benitez, J., Ayuso, C., Beneyto, M., Baiget, M., Gonzalez-Duarte, R. Evidence against involvement of recoverin in autosomal recessive retinitis pigmentosa in 42 Spanish families. Hum. Genet. 96: 89-94, 1995. 2. Dizhoor, A. M., Ray, S., Kumar, S., Niemi, G., Spencer, M., Brolley, D., Walsh, K. A., Philipov, P. P., Hurley, J. B., Stryer, L. Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase. Science 251: 915-918, 1991. 3. Freund, C. L., Valle, D. Cloning and initial characterization of the cDNA and gene for human recoverin. (Abstract) Am. J. Hum. Genet. 51 (suppl.) : A6 only, 1992.