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Anti-RAB43 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Ras-related GTP-binding protein 43 (RAB43) is a member ofthe Rassuperfamily. RAB43 is mainly located in endoplasmic reticulum and Golgi, and plays a role as a key regulator of vesicle movement, signal transduction and tethering membrane eventsin membrane trafficking.

Synonyms

B-cell differentiation antigen CD72; Lyb-2; CD72; CD72

Gene Name

RAB43

Gene ID

339122

UniProt

Q86YS6

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RAB43 recombinant protein (Position: Q14-E206) .

Clonality

Polyclonal

Tissue Specificity

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Plays a role in B-cell proliferation and differentiation.

References & Citations

1. Jiang, Y. , Sun, Y. , Hu, J. , Yu, N. , & Xu, H. . (2019) . A germline mutation in rab43 gene identified from a cancer family predisposes to a hereditary liver-colon cancer syndrome. BMC Cancer, 19 (1) . 2. ChunmanLi, ZheWei, YiFan, WeiHuang, YunchaoSu, & HonglinLi, et al. (2017) . The gtpase rab43 controls the anterograde er-golgi trafficking and sorting of gpcrs. Cell Reports. 3. Ming-Zhi, Han, Bin, Huang, An-Jing, & Chen, et al. (2017) . High expression of rab43 predicts poor prognosis and is associated with epithelial-mesenchymal transition in gliomas. Oncology reports.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

CD72 molecule

Subcellular Location

Membrane; Single-pass type II membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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