L-764406
Product Specifications
UNSPSC Description
L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs[1].
Target Antigen
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Field of Research
others
Assay Protocol
https://www.medchemexpress.com/l-764406.html
Smiles
O=S(CC1=NC2=CC=CC=C2N=C1Cl)(C3=CC=CC=C3)=O
Molecular Weight
318.78
References & Citations
[1]L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor g
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121579/L-764406-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121579/
Clinical Information
No Development Reported
CAS Number
227002-04-2
Curated Selection
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