L-764406
L-764406 is a non-thiazolidinedione (TZD) -type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM) . L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs[1].
Product Specifications
CAS Number
[227002-04-2]
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/l-764406.html
Smiles
O=S(CC1=NC2=CC=CC=C2N=C1Cl)(C3=CC=CC=C3)=O
Molecular Formula
C15H11ClN2O2S
Molecular Weight
318.78
References & Citations
[1]L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor g
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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