Anti-PGP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
PGP (phosphoglycolate phosphatase) belongs to the HAD-like hydrolase superfamily. It is an essential intermediate in the biosynthetic pathway of cardiolipin and a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. PGP catalyzes the formation of phosphatidylglycerol from phosphatidylglycerophosphate.
Synonyms
Protein C-ets-1; p54; ETS1; EWSR2
Gene Name
PGP
Gene ID
283871
UniProt
A6NDG6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PGP recombinant protein (Position: M1-G321) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. .
Applications
Flow Cytometry
Field of Research
Cancer, Cardiogenesis, Cardiovascular, Domain Families, Epigenetics and Nuclear Signaling, Oncoproteins, Oncoproteins/Suppressors, Transcription, Transcription Factors, Transcription Factors/Regulators
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor. ly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. .
References & Citations
1. Amorim, A., Siebert, G., Ritter, H., Kompf, J. Formal genetics of phosphoglycolate phosphate (PGP) : investigation on 272 mother-child pairs. Hum. Genet. 53: 419-420, 1980. 2. Bale, S. J., Chakravarti, A., Ferrell, R. E., Spence, M. A. Possible heterogeneity in the phosphoglycolate phosphatase (PGP) -haptoglobin alpha (HPA) linkage. Am. J. Hum. Genet. 36: 808-814, 1984. 3. Barker, R. F., Hopkinson, D. A. Genetic polymorphism of human phosphoglycolate phosphatase (PGP) . Ann. Hum. Genet. 42: 143-151, 1978.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
50408 MW
Applications Notes
6
Gene Name Synonym
Protein C-ets-1
Subcellular Location
Cytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .
Protein Name
Protein C-ets-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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