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Anti-PLCD3 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene. This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3) . Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca (2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.

Synonyms

PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5; PFM2

Gene Name

PLCD3

Gene ID

113026

UniProt

Q8N3E9

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PLCD3 recombinant protein (Position: R10-Q702) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.

Applications

Flow Cytometry

Field of Research

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.

References & Citations

1. Ghosh, S., Pawelczyk, T., Lowenstein, J. M. Phospholipase C isoforms delta-1 and delta-3 from human fibroblasts: high-yield expression in Escherichia coli, simple purification, and properties. Protein Expr. Purif. 9: 262-278, 1997. 2. Kim, H., Suh, P. G., Ryu, S. H., Park, S. H. Assignment of the human PLC-delta-3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 87: 209-210, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

104553 MW

Applications Notes

6

Gene Name Synonym

PR/SET domain 5

Subcellular Location

Nucleus.

Protein Name

AP-2 complex subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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