Anti-EIF4ENIF1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene. The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
Spermine oxidase; Polyamine oxidase 1; PAO-1; PAOh1; Smox; Smo
Gene Name
EIF4ENIF1
Gene ID
56478
UniProt
Q9NRA8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human EIF4ENIF1 recombinant protein (Position: D13-Q985) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Isoform 1 and isoform 2 are expressed at higher level in brain and skeletal muscle. Isoform 7 is found in brain and spleen, isoform 10 is widely expressed but found at lower level in heart, kidney, liver and lung.
Applications
Flow Cytometry
Field of Research
Chemokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N1-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
References & Citations
1. Dostie, J., Ferraiuolo, M., Pause, A., Adam, S. A., Sonenberg, N. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5-prime cap-binding protein, eIF4E. EMBO J. 19: 3142-3156, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A05520-2-Fluoro647
Calculated Molecular Weight
48608 MW
Applications Notes
6
Gene Name Synonym
Spermine oxidase
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm.
Protein Name
Serine protease HTRA3
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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