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Anti-OPLAH Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD) .

Synonyms

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

Gene Name

OPLAH

Gene ID

26873

UniProt

O14841

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OPLAH recombinant protein (Position: H788-E1072) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Applications

Flow Cytometry

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

References & Citations

1. Almaghlouth, I. A., Mohamed, J. Y., Al-Amoudi, M., Al-Ahaidib, L., Al-Odaib, A., Alkuraya, F. S. 5-Oxoprolinase deficiency: report of the first human OPLAH mutation. Clin. Genet. 82: 193-196, 2012. 2. Calpena, E., Casado, M., Martinez-Rubio, D., Nascimento, A., Colomer, J., Gargallo, E., Garcia-Cazorla, A., Palau, F., Artuch, R., Espinos, C. 5-Oxoprolinuria in heterozygous patients for 5-oxoprolinase (OPLAH) missense changes. JIMD Rep. 7: 123-128, 2013. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 9/22/2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Eva-1 homolog A, regulator of programmed cell death

Subcellular Location

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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