Anti-RTL3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene. This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell.
Synonyms
Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10; RTL10; BOP, C22orf29
Gene Name
RTL3
Gene ID
203430
UniProt
Q8N8U3
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human RTL3 recombinant protein (Position: Q168-Q475) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed.
Applications
Flow Cytometry
Field of Research
Chemokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Could induce apoptosis in a BH3 domain-dependent manner. The interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.
References & Citations
1. Jürgen Brandt, Schrauth, S. , Veith, A. M. , Froschauer, A. , Haneke, T. , & Schultheis, C. , et al. (2005) . Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene, 345 (1), 101-111. 2. Brandt, J. , Veith, A. M. , & Volff, J. N. . (2005) . A family of neofunctionalized ty3/gypsy retrotransposon genes in mammalian genomes. Cytogenetic & Genome Research, 110 (1-4), 307-317. 3. Ota, T. , Suzuki, Y. , Nishikawa, T. , Otsuki, T. , & Sugano, S. . (2004) . Complete sequencing and characterization of 21,243 full-length human cdnas. Nature Genetics, 36 (1), 40-45.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
14377 MW
Applications Notes
6
Gene Name Synonym
Retrotransposon Gag like 10
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Name
Lymphocyte antigen 6A-2/6E-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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