Anti-PGAM1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms
Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a; ITGAL; CD11A
Gene Name
PGAM1
Gene ID
5223
UniProt
P18669
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PGAM1 recombinant protein (Position: Q43-K254) .
Clonality
Polyclonal
Tissue Specificity
Leukocytes.
Applications
Flow Cytometry
Field of Research
Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
References & Citations
1. Charles, D. J., Pretsch, W. Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat. Res. 176: 81-91, 1987. 2. Chen, S.-H., Anderson, J., Giblett, E. R., Lewis, M. Phosphoglyceric acid mutase: rare genetic variants and tissue distribution. Am. J. Hum. Genet. 26: 73-77, 1974. 3. Chen, S.-H., Anderson, J. E., Giblett, E. R. Human red cell 2,3-diphosphogl ycerate mutase and monophosphoglycerate mutase: genetic evidence for two separate loci. Am. J. Hum. Genet. 29: 405-407, 1977.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
128770 MW
Applications Notes
6
Gene Name Synonym
Integrin alpha-L
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Integrin alpha-L
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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