Anti-PATL2 Antibody Picoband® Fluoro647 Conjugated

Predicted to enable RNA binding activity. Predicted to be involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Predicted to act upstream of or within negative regulation of cytoplasmic mRNA processing body assembly. Located in cytoplasm.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Chen, B., Zhang, Z., Sun, X., Kuang, Y., Mao, X., Wang, X., Yan, Z., Li, B., Xu, Y., Yu, M., Fu, J., Mu, J., Zhou, Z., Li, Q., Jin, L., He, L., Sang, Q., Wang, L. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am. J. Hum. Genet. 101: 609-615, 2017. 2. Maddirevula, S., Coskun, S., Alhassan, S., Elnour, A., Alsaif, H. S., Ibrahim, N., Abdulwahab, F., Arold, S. T., Alkuraya, F. S. Female infertility caused by mutations in the oocyte-specific translational repressor PATL2. Am. J. Hum. Genet. 101: 603-608, 2017. 3. Scheller, N., Resa-Infante, P., de la Luna, S., Galao, R. P., Albrecht, M., Kaestner, L., Lipp, P., Lengauer, T., Meyerhans, A., Diez, J. Identification of PatL1, a human homolog to yeast P body component Pat1. Biochim. Biophys. Acta 1773: 1786-1792, 2007.