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Anti-OPTC Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Opticin is a protein that in humans is encoded by the OPTC gene. Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1) .

Synonyms

One cut domain family member 2; Hepatocyte nuclear factor 6-beta; HNF-6-beta; One cut homeobox 2; Transcription factor ONECUT-2; OC-2; ONECUT2; HNF6B

Gene Name

OPTC

Gene ID

26254

UniProt

Q9UBM4

Host

Rabbit

Reactivity

Human, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OPTC recombinant protein (Position: E32-Q250) .

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Applications

Flow Cytometry

Field of Research

Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

References & Citations

1. Friedman, J. S., Faucher, M., Hiscott, P., Biron, V. L., Malenfant, M., Turcotte, P., Raymond, V., Walter, M. A. Protein localization in the human eye and genetic screen of opticin. Hum. Molec. Genet. 11: 1333-1342, 2002. 2. Reardon, A. J., Le Goff, M., Briggs, M. D., McLeod, D., Sheehan, J. K., Thornton, D. J., Bishop, P. N. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. J. Biol. Chem. 275: 2123-2129, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

One cut homeobox 2

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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