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Anti-TMEM132B Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Predicted to be integral component of membrane.

Synonyms

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

Gene Name

TMEM132B

Gene ID

114795

UniProt

Q14DG7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TMEM132B recombinant protein (Position: H123-M1078) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Farlow, J. L. , Hai, L. , Laura, S. , Lai, D. , Koller, D. L. , & Elizabeth, P. , et al. (2015) . Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. PLoS ONE, 10 (3), e0121104-. 2. Luis, S. P. , & Ponting, C. P. . (2018) . Tmem132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. Bioinformatics (5), 721-724. 3. Winham, S. J. , Cuellar-Barboza, A. B. , Oliveros, A. , Mcelroy, S. L. , & Biernacka, J. M. . (2013) . Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in tcf7l2. Molecular Psychiatry, 19 (9), 1010.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A16132-1-Fluoro488

Calculated Molecular Weight

24145 MW

Applications Notes

6

Gene Name Synonym

Kelch repeat and BTB domain containing 2

Subcellular Location

Cul3-RING ubiquitin ligase complex.

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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