Anti-TMEM87A Antibody Picoband® Fluoro647 Conjugated

Accessory component of the proton-transporting vacuolar (V) -ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis.

1. Patkunarajah, A. , Stear, J. H. , Moroni, M. , Schroeter, L. , & Poole, K. . (2020) . Tmem87a/elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration. eLife Sciences Publications, Ltd. 2. Hirata, T. , Fujita, M. , Nakamura, S. , Gotoh, K. , Motooka, D. , & Murakami, Y. , et al. (2015) . Post-golgi anterograde transport requires garp-dependent endosome-to-tgn retrograde transport. Molecular Biology of the Cell, 3071-3084. 3. Christian, S. L. , Fantes, J. A. , Mewborn, S. K. , Bing, H. , & Ledbetter, D. H. . Large genomic duplicons map to sites of instability in the prader-willi/angelman syndrome chromosome region (15q11-q13) . Human Molecular Genetics (6), 1025-1037.

Endoplasmic reticulum membrane. Multi-pass membrane protein. COPI-coated vesicle membrane. Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein.