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Anti-RPRD1B Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation; regulation of cell cycle process; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II, holoenzyme.

Synonyms

Fascin-2; Retinal fascin; FSCN2

Gene Name

RPRD1B

Gene ID

58490

UniProt

Q9NQG5

Host

Rabbit

Reactivity

Human, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RPRD1B recombinant protein (Position: R79-K272) .

Clonality

Polyclonal

Tissue Specificity

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

Applications

Flow Cytometry

Field of Research

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

References & Citations

1. Hartz, P. A. Personal Communication. Baltimore, Md. 6/22/2012. 2. Lu, D., Wu, Y., Wang, Y., Ren, F., Wang, D., Su, F., Zhang, Y., Yang, X., Jin, G., Hao, X., He, D., Zhai, Y., Irwin, D. M., Hu, J., Sung, J. J. Y., Yu, J., Jia, B., Chang, Z. CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes. Cancer Cell 21: 92-104, 2012. 3. Ni, Z., Olsen, J. B., Guo, X., Zhong, G., Ruan, E. D., Marcon, E., Young, P., Guo, H., Li, J., Moffat, J., Emili, A., Greenblatt, J. F. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription 2: 237-242, 2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

49229 MW

Applications Notes

6

Gene Name Synonym

Fascin actin-bundling protein 2, retinal

Subcellular Location

Nucleus.

Protein Name

Chromaffin granule amine transporter

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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