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Anti-ST6GALNAC2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 is an enzyme that in humans is encoded by the ST6GALNAC2 gene. ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting.

Synonyms

Pre T-cell antigen receptor alpha; pT-alpha; pTa; pT-alpha-TCR; PTCRA

Gene Name

ST6GALNAC2

Gene ID

10610

UniProt

Q9UJ37

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ST6GALNAC2 recombinant protein (Position: Q32-R374) .

Clonality

Polyclonal

Tissue Specificity

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Applications

Flow Cytometry

Field of Research

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Form

Liquid

Function

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. .

References & Citations

1. Samyn-Petit, B., Krzewinski-Recchi M.-A., Steelant, W. F. A., Delannoy, P., Harduin-Lepers, A. Molecular cloning and functional expression of human ST6GalNAc II: molecular expression in various human cultured cells. Biochim. Biophys. Acta 1474: 201-211, 2000. 2. Sotiropoulou, G., Kono, M., Anisowicz, A., Stenman, G., Tsuji, S., Sager, R. Identification and functional characterization of a human GalNAc alpha-2,6-sialyltransferase with altered expression in breast cancer. Molec. Med. 8: 42-55, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41409 MW

Applications Notes

6

Gene Name Synonym

Pre T cell antigen receptor alpha

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Protein NDRG3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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