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Anti-OPA1 Antibody Picoband®

Boster Bio Anti-OPA1 Antibody Picoband® catalog # A00508-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Hereditary hemochromatosis protein; HLA-H; HFE; HLAH

Gene Name

OPA1

Gene ID

4976

UniProt

O60313

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OPA1 recombinant protein (Position: D296-Q562) .

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues tested except brain.

Applications

WB, ICC, IF, Flow Cytometry, ELISA

Field of Research

Cofactors, Vitamins/Minerals, Hematopoietic Progenitors, Metabolism, Myeloid, Pathways and Processes, Signal Transduction, Stem Cells, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. .

References & Citations

1. Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS (Nov 2014) . OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. The EMBO Journal 33 (22) : 2676–91. 2. Santarelli R, Rossi R, Scimemi P, Cama E, Valentino ML, La Morgia C, Caporali L, Liguori R, Magnavita V, Monteleone A, Biscaro A, Arslan E, Carelli V (Mar 2015) . OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation. Brain 138 (Pt 3) : 563–76.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

40108 MW

Observed Molecular Weight

80-100 kDa

Applications Notes

6

Gene Name Synonym

Hereditary hemochromatosis protein

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Protein Name

Hereditary hemochromatosis protein

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

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