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Anti-OLFML2B Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins.

Synonyms

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

Gene Name

OLFML2B

Gene ID

25903

UniProt

Q68BL8

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OLFML2B recombinant protein (Position: I23-N671) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Liu, J. , Liu, Z. , Zhang, X. , Gong, T. , & Yao, D. . (2019) . Bioinformatic exploration of olfml2b overexpression in gastric cancer base on multiple analyzing tools. BMC Cancer, 19 (1), 1-10. 2. Nolte, I. M. , Wallace, C. , Newhouse, S. J. , Waggott, D. , Fu, J. , & Soranzo, N. , et al. (2009) . Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS ONE, 4 (7), e6138. 3. Reiner, A. , Beleza, S. , Franceschini, N. , Auer, P. , Robinson, J. , & Kooperberg, C. , et al. (2012) . Genome-wide association and population genetic analysis of c-reactive protein in african american and hispanic american women. The American Journal of Human Genetics, 91 (3), 502-512.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A16481-2-Fluoro594

Calculated Molecular Weight

24145 MW

Applications Notes

6

Gene Name Synonym

Kelch repeat and BTB domain containing 2

Subcellular Location

Cul3-RING ubiquitin ligase complex.

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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