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Anti-OLAH Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Enables dodecanoyl-[acyl-carrier-protein] hydrolase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; and palmitoyl-[acyl-carrier-protein] hydrolase activity. Involved in medium-chain fatty acid biosynthetic process. Predicted to be located in cytosol.

Synonyms

Matrix metalloproteinase-16; MMP-16; 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; MMP16; MMPX2

Gene Name

OLAH

Gene ID

55301

UniProt

Q9NV23

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OLAH recombinant protein (Position: E13-F265) .

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

References & Citations

1. Ritchie, M. K. , Johnson, L. C. , Clodfelter, J. E. , Pemble, C. W. , Fulp, B. E. , & Furdui, C. M. , et al. (2015) . Crystal structure and substrate specificity of human thioesterase 2: insights into the molecular basis for the modulation of fatty acid synthase. Journal of Biological Chemistry, 3520-3530. 2. Nobuo, N. , Yasunori, S. , Takahiro, T. , Hiroaki, O. , Daisuke, O. , & Hanjun, Z. , et al. (2006) . Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. Dna Research An International Journal for Rapid Publication of Reports on Genes & Genomes, 13 (4), 169. 3. Grupe, A. , Li, Y. , Rowland, C. , Nowotny, P. , Hinrichs, A. L. , & Smemo, S. , et al. (2006) . A scan of chromosome 10 identifies a novel locus showing strong association with late-onset alzheimer disease. The American Journal of Human Genetics, 78 (1), 78-88.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

39125 MW

Applications Notes

6

Gene Name Synonym

Matrix metallopeptidase 16

Subcellular Location

Isoform Long: Cell membrane ; Localized at the cell surface of melanoma cells.

Protein Name

RNA-binding protein Musashi homolog 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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