Anti-OLAH Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Enables dodecanoyl-[acyl-carrier-protein] hydrolase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; and palmitoyl-[acyl-carrier-protein] hydrolase activity. Involved in medium-chain fatty acid biosynthetic process. Predicted to be located in cytosol.
Synonyms
Matrix metalloproteinase-16; MMP-16; 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; MMP16; MMPX2
Gene Name
OLAH
Gene ID
55301
UniProt
Q9NV23
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human OLAH recombinant protein (Position: E13-F265) .
Clonality
Polyclonal
Tissue Specificity
Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes
Purification
Immunogen affinity purified.
Form
Liquid
Function
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
References & Citations
1. Ritchie, M. K. , Johnson, L. C. , Clodfelter, J. E. , Pemble, C. W. , Fulp, B. E. , & Furdui, C. M. , et al. (2015) . Crystal structure and substrate specificity of human thioesterase 2: insights into the molecular basis for the modulation of fatty acid synthase. Journal of Biological Chemistry, 3520-3530. 2. Nobuo, N. , Yasunori, S. , Takahiro, T. , Hiroaki, O. , Daisuke, O. , & Hanjun, Z. , et al. (2006) . Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. Dna Research An International Journal for Rapid Publication of Reports on Genes & Genomes, 13 (4), 169. 3. Grupe, A. , Li, Y. , Rowland, C. , Nowotny, P. , Hinrichs, A. L. , & Smemo, S. , et al. (2006) . A scan of chromosome 10 identifies a novel locus showing strong association with late-onset alzheimer disease. The American Journal of Human Genetics, 78 (1), 78-88.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39125 MW
Applications Notes
6
Gene Name Synonym
Matrix metallopeptidase 16
Subcellular Location
Isoform Long: Cell membrane ; Localized at the cell surface of melanoma cells.
Protein Name
RNA-binding protein Musashi homolog 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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