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Anti-OIP5 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Protein SOX-15; Protein SOX-12; Protein SOX-20; SOX15; SOX12; SOX20; SOX26; SOX27

Gene Name

OIP5

Gene ID

11339

UniProt

O43482

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OIP5 recombinant protein (Position: M1-N229) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

Applications

Flow Cytometry

Field of Research

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds to the 5'-AACAAT-3' sequence.

References & Citations

1. Fujita, Y., Hayashi, T., Kiyomitsu, T., Toyoda, Y., Kokubu, A., Obuse, C., Yanagida, M. Priming of centromere for CENP-A recruitment by human hMi18-alpha, hMis18-beta, and M18BP1. Dev. Cell 12: 17-30, 2007. 2. Gross, M. B. Personal Communication. Baltimore, Md. 10/2/2018. 3. Nardi, I. K., Zasadzinska, E., Stellfox, M. E., Knippler, C. M., Foltz, D. R. Licensing of centromeric chromatin assembly through the Mis18-alpha-Mis18-beta heterotetramer. Molec. Cell 61: 774-787, 2016.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

49229 MW

Applications Notes

6

Gene Name Synonym

SRY-box 15

Subcellular Location

Nucleus.

Protein Name

Chromaffin granule amine transporter

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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