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Anti-OGFOD2 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Predicted to enable several functions, including L-ascorbic acid binding activity; dioxygenase activity; and iron ion binding activity.

Synonyms

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

Gene Name

OGFOD2

Gene ID

79676

UniProt

Q6N063

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OGFOD2 recombinant protein (Position: R8-R293) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Ripke, S. , O'Dushlaine, C. , Chambert, K. , Moran, J. L. , & Kahler, A. K. . (2013) . Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics. 2. Abraham, C. G. , Ludwig, M. P. , Andrysik, Z. , Galbraith, M. D. , Sullivan, K. D. , & Correspondence, J. M. E. . Δnp63α suppresses tgfb2 expression and rhoa activity to drive cell proliferation in squamous cell carcinomas. Cell reports, 24 (12), 3224-3236. 3. Ripke, S. , Neale, B. M. , Corvin, A. , Walters, J. , Farh, K. H. , & Al, E. . Biological insights from 108 schizophrenia-associated genetic loci. Nature.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

24145 MW

Applications Notes

6

Gene Name Synonym

Kelch repeat and BTB domain containing 2

Subcellular Location

Cul3-RING ubiquitin ligase complex.

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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