Anti-RTF1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) is a protein that in humans is encoded by the RTF1 gene. This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA.
Synonyms
Protein phosphatase 1 regulatory subunit 14A;17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17; PPP1R14A; CPI17, PPP1INL
Gene Name
RTF1
Gene ID
23168
UniProt
Q92541
Host
Rabbit
Reactivity
Human, Monkey
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human RTF1 recombinant protein (Position: S77-K705) .
Clonality
Polyclonal
Tissue Specificity
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. .
Applications
Flow Cytometry
Field of Research
Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
References & Citations
1. Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N., Nomura, N. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 3: 321-329, 1996. 2. Warner, M. H., Roinick, K. L., Arndt, K. M. Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by ing cotranscriptional histone modification. Molec. Cell. Biol. 27: 6103-6115, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
16693 MW
Applications Notes
6
Gene Name Synonym
Protein phosphatase 1 regulatory subunit 14A
Subcellular Location
Cytoplasm .
Protein Name
Protein phosphatase 1 regulatory subunit 14A
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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